Objective: To reassess endometrial morphological criteria of normality identifying the best morphological and molecular “implantation window” indicators in normal women. Result(s): In 26 of 28 biopsies observers agreed; in two biopsies there was a discrepancy (difference of 72 hours).
Meanwhile, continued use of the criteria of Noyes et al for endometrial dating is recommended until more precise modalities for assessing the adequacy of endometrial maturation are available.
Absence of organic endometrial disease and availability of accurate menstrual history were the only selection criteria. 42 of the 300 patients (14%) menstruated on the day predicted, 36 (12%) menstruated later, and 222 (74%) menstruated earlier.
When a or- 1 day error was allowed, 112 patients (38%) were found to menstruate at the time predicted.
From the *Department of Pathology and †Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.
Reprints: Wenxin Zheng, MD, Department of Pathology, Yale University School of Medicine, 20 York St., EP 2-608, New Haven, CT 06520-8070 (e-mail: [email protected]).
Pinopodes appeared on days 20–21 and persisted through day 28 in small groups or larger areas.